I te pakeketanga o te kiri, ka heke te mahi ā-tinana. Ko ēnei huringa ka puta mai i ngā āhuatanga ā-roto (ā-wā) me ngā āhuatanga ā-waho (ko te nuinga nā te UV). Ka tukuna e ngā tipu he painga pea hei whawhai i ētahi o ngā tohu o te koroheketanga. I konei, ka arotakehia e mātou ētahi tipu kua tohua me ngā taunakitanga pūtaiao kei muri i ā rātou kereme ārai-pakeketanga. Ka tukuna pea e ngā tipu he ārai-mumura, he ārai-waipiro, he whakamakuku, he tiaki-UV, me ētahi atu pānga. He maha ngā tipu kua whakarārangihia hei kai i roto i ngā whakapaipai me ngā rongoā whakapaipai rongonui, engari he torutoru noa iho ka kōrerohia i konei. I whiriwhiria ēnei i runga i te wātea o ngā raraunga pūtaiao, te hiahia whaiaro o ngā kaituhi, me te "rongonui" o ngā hua whakapaipai me ngā hua whakapaipai o nāianei. Ko ngā tipu kua arotakehia i konei ko te hinu argan, te hinu kokonati, te crocin, te feverfew, te tī matomato, te marigold, te pamekaranete, me te soy.
Ngā Kupumatua: tipu; ārai-koroheketanga; hinu argan; hinu kokonati; crocin; feverfew; tī matomato; marigold; pamekaranete; soy
3.1. Hinu Ākana
3.1.1. Hītori, Whakamahinga, me ngā Kereme
He whenua taketake te hinu argan ki Morocco, ā, i ahu mai i ngā kākano o te Argania sponosa L. He maha ngā whakamahinga tuku iho o tēnei hinu, pērā i te tunu kai, te rongoā i ngā mate kiri, me te tiaki kiri me te makawe.
3.1.2. Te Hanganga me te Tikanga Mahi
Ko te hinu argan he mea tito mai i te 80% ngako monounsaturated me te 20% waikawa ngako kukū, ā, kei roto hoki ngā polyphenols, tocopherols, sterols, squalene, me te waipiro triterpene.
3.1.3. Ngā Taunakitanga Pūtaiao
Kua whakamahia te hinu argan i Moroko hei whakaiti i te tae o te mata, engari kāore i mārama i mua te pūtake pūtaiao mō tēnei kereme. I roto i tētahi rangahau kiore, i aukati te hinu argan i te whakaaturanga tyrosinase me te dopachrome tautomerase i roto i ngā pūtau melanoma murine B16, ā, ka heke te ihirangi melanin i runga i te horopeta. E kī ana tēnei he kaha pea te aukati o te hinu argan i te hanga melanin, engari me whai whakamātautau whakahaere matapōkere (RTC) i roto i ngā tāngata hei manatoko i tēnei whakapae.
I whakaarohia e tētahi RTC iti o te 60 wāhine kua pāngia e te mate pāwera ko te kai i ia rā, i te paninga rānei o te hinu argan i whakaiti i te ngaronga wai transepidermal (TEWL), i whakapai ake i te ngāwari o te kiri, i runga i te pikinga o te R2 (te ngāwari katoa o te kiri), R5 (te ngāwari kupenga o te kiri), me te R7 (te ngāwari koiora) me te hekenga o te wā rere oro (RRT) (he inenga e pā ana ki te ngāwari o te kiri). I whakaritea matapōkeretia ngā rōpū ki te kai i te hinu oriwa, i te hinu argan rānei. I pania e ngā rōpū e rua te hinu argan ki te ringaringa volar maui anake. I tangohia ngā inenga mai i ngā ringaringa volar matau me maui. I kitea ngā whakapainga o te ngāwari i roto i ngā rōpū e rua i te ringaringa i pania ai te hinu argan ki te kiri, engari i te ringaringa kāore i pania te hinu argan ko te rōpū anake e kai ana i te hinu argan i piki ake te ngāwari [31]. I pāngia tēnei e te nui haere o te ihirangi antioxidant i roto i te hinu argan ki te hinu oriwa. E whakapaetia ana ko te take pea tēnei nā te Huaora E me te ihirangi waikawa ferulic, e mōhiotia ana he antioxidants.
3.2. Hinu Kokonati
3.2.1. Hītori, Whakamahinga, me ngā Kereme
I ahu mai te hinu kokonati i te hua maroke o Cocos nucifera, ā, he maha ngā whakamahinga, mai i ngā wā o mua, mai i ēnei rā anō hoki. Kua whakamahia hei kakara, hei whakakaha kiri, hei whakangawari makawe, ā, i roto hoki i ngā hua whakapaipai maha. Ahakoa he maha ngā momo matū o te hinu kokonati, tae atu ki te waikawa kokonati, te waikawa kokonati hauwai, me te hinu kokonati hauwai, ka matapakihia e tātou ngā kereme rangahau e pā ana ki te hinu kokonati wahine (VCO), e hangaia ana me te kore wera.
Kua whakamahia te hinu kokonati hei whakamakuku i te kiri o ngā pēpi, ā, tera pea he pai mō te rongoā i te mate kiri kiri nā ōna āhuatanga whakamakuku me ōna pānga pea ki te Staphylococcus aureus me ētahi atu moroiti kiri i roto i ngā tūroro kiri kiri kiri. Kua whakaaturia te hinu kokonati ka whakaiti i te noho o te S. aureus ki te kiri o ngā pakeke e pangia ana e te mate kiri ...
3.2.2. Te Hanganga me te Tikanga Mahi
Ko te hinu kokonati he mea tito mai i te 90–95% o ngā triglycerides kukū (waikawa lauric, waikawa myristic, waikawa caprylic, waikawa capric, me te waikawa palmitic). He rerekē tēnei ki te nuinga o ngā hinu huawhenua/huawhenua, he nui te ngako kore kukū. Ko ngā triglycerides kukū e pania ana ki te kiri ka mahi hei whakamakuku i te kiri hei whakangawari mā te whakawhāiti i ngā taha maroke me te miro o ngā corneocytes me te whakakī i ngā āputa i waenganui i a rātou.
3.2.3. Ngā Taunakitanga Pūtaiao
Ka taea e te hinu kokonati te whakamakuku i te kiri maroke kua koroheke. E ono tekau mā rua ōrau o ngā waikawa ngako i roto i te VCO he rite te roa, ā, e 92% he mātotoru, e āhei ai te whakakīkī ake, ka hua ake he pānga ārai nui atu i te hinu oriwa. Ka pakaruhia ngā triglycerides i roto i te hinu kokonati e ngā lipase i roto i ngā tipu kiri noa ki te glycerin me ngā waikawa ngako. He humectant kaha te glycerin, e kukume ana i te wai ki te paparanga corneal o te epidermis mai i te taiao o waho me ngā paparanga kiri hohonu ake. He iti te ihirangi waikawa linoleic o ngā waikawa ngako i roto i te VCO, he mea nui tēnei nā te mea ka taea e te waikawa linoleic te whakapataritari i te kiri. He pai ake te hinu kokonati i te hinu kohuke ki te whakaiti i te TEWL i roto i ngā tūroro e pāngia ana e te atopic dermatitis, ā, he rite te whai hua me te haumaru ki te hinu kohuke ki te rongoā i te xerosis.
Ko te waikawa lauric, he matū mua mō te monolaurin, he wāhanga nui hoki o te VCO, tera pea he āhuatanga ārai-mumura, ka taea te whakahaere i te tipu o ngā pūtau ārai mate, ā, koia hoki te take o ētahi o ngā pānga patu huakita o te VCO. Kei roto i te VCO he nui te waikawa ferulic me te waikawa p-coumaric (he waikawa phenolic ēnei e rua), ā, ko ngā taumata tiketike o ēnei waikawa phenolic e pā ana ki te pikinga o te kaha ārai-pūmua. He whai hua ngā waikawa phenolic ki te ārai i ngā kino i puta mai i te UV. Heoi, ahakoa ngā kereme ka taea e te hinu kokonati te mahi hei pare-rā, e kī ana ngā rangahau in vitro he iti noa iho, kāore rānei, te kaha ārai-UV.
Haunga ōna pānga whakamakuku me te ārai mate, e kī ana ngā tauira kararehe ka taea e te VCO te whakaiti i te wā whakaora patunga. I kitea he nui ake te taumata o te collagen wairewa-pepsin (he nui ake te hononga-whakawhiti collagen) i roto i ngā patunga i rongoatia ki te VCO ki te whakataurite ki ngā mana whakahaere. I whakaatuhia e te histopathology te pikinga o te tipu fibroblast me te neovascularization i roto i ēnei patunga. Me nui ake ngā rangahau hei tirotiro mena ka taea e te paninga o te VCO ki te kiri kakano te whakanui ake i ngā taumata collagen i roto i te kiri tangata kua koroheke.
3.3. Korokini
3.3.1. Hītori, Whakamahinga, Kereme
He wāhanga koiora kaha te korocine o te saffron, i ahu mai i te stigma maroke o Crocus sativus L. E whakatipuria ana te saffron i roto i te maha o ngā whenua tae atu ki a Īrāna, Īnia, me Kariki, ā, kua whakamahia i roto i ngā rongoā tuku iho hei whakaora i ngā momo mate tae atu ki te pouri, te mumura, te mate ate, me te maha atu.
3.3.2. Te Hanganga me te Tikanga Mahi
Ko te korocin te take o te tae o te saffron. Kei roto hoki i te hua o Gardenia jasminoides Ellis te korocin. E whakarōpūtia ana hei carotenoid glycoside.
3.3.3. Ngā Taunakitanga Pūtaiao
He pānga ārai-mate te Crocin, he tiaki i te squalene mai i te peroxidation i puta mai i te UV, ā, ka ārai i te tukunga o ngā takawaenga mumura. Kua whakaaturia te pānga ārai-mate i roto i ngā whakamātautau in vitro i whakaatu i te kaha ārai-mate pai ake i te Huaora C. Hei tāpiri, ka ārai te crocin i te peroxidation o te membrane pūtau i puta mai i te UVA, ā, ka ārai i te whakaaturanga o ngā takawaenga pro-inflammatory maha tae atu ki te IL-8, PGE-2, IL-6, TNF-α, IL-1α, me te LTB4. Ka whakaitihia hoki te whakaaturanga o ngā ira maha e whakawhirinaki ana ki te NF-κB. I roto i tētahi rangahau e whakamahi ana i ngā fibroblasts tangata kua whakatipuria, i whakaitihia e te crocin te ROS i puta mai i te UV, i whakatairanga i te whakaaturanga o te pūmua matrix extracellular Col-1, ā, i whakaitihia te maha o ngā pūtau me ngā momo tawhito i muri i te hihi UV. Ka whakaitihia te hanga ROS, ā, ka whakawhāitihia te apoptosis. I whakaaturia te Crocin ki te pehi i ngā ara tohu ERK/MAPK/NF-κB/STAT i roto i ngā pūtau HaCaT in vitro. Ahakoa he kaha te crocin hei rongoā anti-pakeke, he ngoikore te matū. Kua rangahaua te whakamahinga o ngā dispersions lipid nanostructured mō te whakahaere ā-papa me ngā hua whai hua. Hei whakatau i ngā pānga o te crocin in vivo, e hiahiatia ana ētahi atu tauira kararehe me ngā whakamātautau haumanu matapōkere.
3.4. Te Whewhe
3.4.1. Hītori, Whakamahinga, Kereme
He otaota ā-tau te Tanacetum parthenium, he ingoa rongonui, kua whakamahia mō ngā kaupapa maha i roto i te rongoā tuku iho.
3.4.2. Te Hanganga me te Tikanga Mahi
Kei roto i te Feverfew te parthenolide, he sesquiterpene lactone, e whai pānga ana pea ki ētahi o ōna pānga ārai-mumura, mā te aukati i te NF-κB. Ko te āhua nei kāore tēnei aukati i te NF-κB e pā ana ki ngā pānga ārai-pūmua o te parthenolide. Kua whakaatuhia hoki e te Parthenolide he pānga ārai-matepukupuku ki te matepukupuku kiri i puta mai i te UVB me ngā pūtau melanoma i roto i te vitro. Engari, ka taea hoki e te parthenolide te whakaputa i ngā mate pāwera, ngā pupuhi waha, me te mate pāwera ki te kiri. Nā ēnei āwangawanga, ka tangohia ināianei i mua i te tāpiritanga o te feverfew ki ngā hua whakapaipai.
3.4.3. Ngā Taunakitanga Pūtaiao
Nā te mea ka pā mai pea ngā raruraru ki te whakamahinga o te parthenolide i runga i te kiri, ko ētahi o ngā hua whakapaipai o nāianei kei roto ko te feverfew e whakamahi ana i te parthenolide-depleted feverfew (PD-feverfew), e kīia ana kāore he kaha ki te whakararuraru. Ka taea e te PD-feverfew te whakarei ake i te mahi whakatikatika DNA taketake i roto i te kiri, ka whakaiti pea i te kino o te DNA i puta mai i te UV. I roto i tētahi rangahau in vitro, i whakaitihia e te PD-feverfew te hanganga hauwai peroxide i puta mai i te UV me te whakaiti i te tukunga o te cytokine mumura. I whakaatuhia he kaha ake ngā pānga antioxidant i te whakataurite, Huaora C, ā, i whakaitihia te whero i puta mai i te UV i roto i tētahi RTC 12-tūroro.
3.5. Tī Kakariki
3.5.1. Hītori, Whakamahinga, Kereme
Kua roa te whakamahinga o te tī matomato i Haina mō ōna painga hauora. Nā te kaha o ōna pānga antioxidant, kei te hiahia te tangata ki te whakawhanake i tētahi ranunga kiri pumau, e wātea ana i te tinana.
3.5.2. Te Hanganga me te Tikanga Mahi
Kei roto i te tī matomato, mai i te Camellia sinensis, he maha ngā matū koiora e whai pānga ana ki te koroheketanga, tae atu ki te kawheine, ngā huaora, me ngā polyphenols. Ko ngā polyphenols matua i roto i te tī matomato ko ngā catechins, inā koa ko te gallocatechin, te epigallocatechin (ECG), me te epigallocatechin-3-gallate (EGCG). He āhuatanga antioxidant, photoprotective, immunomodulatory, anti-angiogenic, me te anti-inflammatory a te Epigallocatechin-3-gallate. Kei roto hoki i te tī matomato te nui o te flavonol glycoside kaempferol, e pai ana te mimiti ki te kiri i muri i te paninga ki te kiri.
3.5.3. Ngā Taunakitanga Pūtaiao
Ka whakaitihia e te tangohanga tī matomato te hanga ROS ā-roto i roto i te vitro, ā, kua whakaitihia te necrosis i puta mai i te ROS. Ka aukatihia e te Epigallocatechin-3-gallate (he polyphenol tī matomato) te tukunga o te hauwai peroxide i puta mai i te UV, ka pehi i te phosphorylation o MAPK, ā, ka whakaitihia te mumura mā te whakahohenga o te NF-κB. Mā te whakamahi i te kiri ex vivo o tētahi wahine hauora 31-tau te pakeke, i mua i te maimoatia o te kiri ki te tangohanga tī mā, tī matomato rānei, i whakaatuhia te pupuri o ngā pūtau Langerhans (ngā pūtau whakaatu-antigen e kawenga ana mō te whakaoho i te ārai mate i roto i te kiri) i muri i te pānga ki te mārama UV.
I roto i tētahi tauira kiore, ko te paninga o te tangohanga tī matomato i mua i te pānga ki te hihi UV i heke ai te whero, te urunga o ngā leukocyte ki te kiri, me te hekenga o te mahi myeloperoxidase. Ka taea hoki e ia te aukati i te 5-α-reductase.
He maha ngā rangahau i uru atu ki ngā tāngata kua arotake i ngā painga pea o te paninga o te tī matomato ki te kiri. Ko te paninga o te hinu tī matomato i aukati i te 5-α-reductase, ā, i heke iho te rahi o te microcomedone i roto i te hakihaki microcomedone. I roto i tētahi rangahau iti e ono wiki te roa mō te tangata, i whakaitihia e tētahi kirīmi kei roto ko te EGCG te hypoxia-inducible factor 1 α (HIF-1α) me te vascular endothelial growth factor (VEGF), e whakaatu ana i te kaha ki te ārai i ngā telangiectasias. I roto i tētahi rangahau matapo-rua, i pania te tī matomato, te tī mā, te waka rānei ki ngā papa o te 10 o ngā tūao hauora. Kātahi ka whakamāramahia te kiri ki te 2× iti rawa te horopeta erythema (MED) o te UVR whakaata-rā. I whakaatuhia e ngā koiora kiri mai i ēnei wāhi ka taea e te paninga o te tangohanga tī matomato, mā rānei te whakaiti i te whakahekenga o ngā pūtau Langerhans, i runga i te pai o te CD1a. I āraihia hoki te kino o te DNA oxidative i puta mai i te UV, e whakaatuhia ana e te hekenga o ngā taumata o te 8-OHdG. I roto i tētahi atu rangahau, i wehea matapōkeretia ngā tūao pakeke e 90 ki ngā rōpū e toru: Kāore he maimoatanga, he tī matomato pania, he tī mā pania rānei. I wehea anō ia rōpū ki ngā taumata rerekē o te hihi UV. I kitea ko te tauwehenga tiaki rā in vivo he tata ki te SPF 1.
3.6. Te Ānikoro
3.6.1. Hītori, Whakamahinga, Kereme
He tipu puawai kakara te marigold, Calendula officinalis, ā, he maha ngā āhuatanga rongoā pea. Kua whakamahia i roto i te rongoā tuku iho i Ūropi me te Hononga o Amerika hei rongoā ā-waha mō ngā wera, ngā maru, ngā motu, me ngā ponana. Kua whakaatuhia hoki e te marigold he pānga ārai matepukupuku i roto i ngā tauira kiore o te matepukupuku kiri kore-melanoma.
3.6.2. Te Hanganga me te Tikanga Mahi
Ko ngā matū matua o te marigold ko ngā steroids, ngā terpenoids, ngā waipiro triterpene kore utu me ngā waipiro esterified, ngā waikawa phenolic, ngā flavonoids, me ētahi atu matū. Ahakoa i whakaatuhia e tētahi rangahau ka taea e te paninga o te tangohanga marigold te whakaiti i te kaha me te mamae o te dermatitis radiation i roto i ngā tūroro e whiwhi ana i te radiation mō te mate pukupuku ū, kāore i whakaatuhia e ētahi atu whakamātautau haumanu he pai ake i te paninga o te kirīmi wai anake.
3.6.3. Ngā Taunakitanga Pūtaiao
Kua whakaatuhia te kaha ātete-aukati o te marigold me ōna pānga paitini ki ngā pūtau matepukupuku tangata i roto i tētahi tauira pūtau kiri tangata in vitro. I roto i tētahi rangahau in vitro motuhake, i arotakehia tētahi kirīmi kei roto te hinu calendula mā te ine UV, ā, i kitea he whānuitanga mimiti kei roto i te awhe 290-320 nm; i tangohia tēnei hei tikanga he pai te tiaki i te rā mā te paninga o tēnei kirīmi. Heoi, he mea nui kia mōhio ehara tēnei i te whakamātautau in vivo i tatau i te horopeta iti rawa o te whero i roto i ngā tūao tangata, ā, kāore anō kia mārama me pēhea te whakamaoritanga o tēnei i roto i ngā whakamātautau haumanu.
I roto i tētahi tauira kiore in vivo, i whakaatuhia e te tangohanga marigold he pānga antioxidant kaha i muri i te pānga UV. I roto i tētahi atu rangahau, i uru atu ai ngā kiore albino, ko te paninga o te hinu kakara calendula i whakaiti i te malondialdehyde (he tohu o te ahotea oxidative) me te whakanui ake i ngā taumata o te catalase, glutathione, superoxide dismutase, me te waikawa ascorbic i roto i te kiri.
I roto i tētahi rangahau matapo-kotahi e waru wiki te roa me te 21 tāngata, ko te paninga o te kirīmi calendula ki ngā paparinga ka whakanui ake i te kikī o te kiri engari kāore he pānga nui ki te ngāwari o te kiri.
Ko tētahi herenga pea ki te whakamahinga o te kūmara i roto i ngā mea whakapaipai, ko te kūmara tetahi o ngā tino take o te mate pāwera me te mate pāwera, pērā i ētahi atu mema o te whānau Compositae.
3.7. Pamekaranete
3.7.1. Hītori, Whakamahinga, Kereme
He kaha te kaha o te pamekaranete, Punica granatum, ki te ārai mate, ā, kua whakamahia i roto i ngā hua maha hei ārai mate ā-waha. Nā te nui o te ihirangi ārai mate e pai ai te whakauru ki ngā whakatakotoranga whakapaipai.
3.7.2. Te Hanganga me te Tikanga Mahi
Ko ngā wāhanga koiora kaha o te pamekaranete ko ngā tannins, ngā anthocyanins, te waikawa ascorbic, te niacin, te pāhare pākawa, me ngā piperidine alkaloids. Ka taea te tango i ēnei wāhanga koiora kaha mai i te wai, i ngā purapura, i te kiri, i te kiri rakau, i te pakiaka, i te kakau rānei o te pamekaranete. E whakaarohia ana ko ētahi o ēnei wāhanga he ārai pukupuku, he ārai mumura, he ārai huakita, he ārai ārai mate, me te ārai whakaahua. Hei tāpiri, he puna kaha te pamekaranete mō ngā polyphenols. Ko te waikawa Ellegic, he wāhanga o te tangohanga pamekaranete, ka whakaiti i te tae kiri. Nā te mea he wāhanga ārai koroheketanga whai hua, he maha ngā rangahau kua rangahau i ngā tikanga hei whakanui ake i te urunga o tēnei matū ki te kiri mō te whakamahinga ā-kiri.
3.7.3. Ngā Taunakitanga Pūtaiao
Ka tiakina e te tangohanga hua pamekaranete ngā pūtau pūtau tangata, i roto i te vitro, mai i te mate pūtau i puta mai i te UV; tērā pea nā te hekenga o te whakahohenga o te NF-κB, te whakahekenga o te caspace-3 proapoptotic, me te pikinga o te whakatikatika DNA. E whakaatu ana i ngā pānga whakatairanga i te pukupuku kiri-ā-kiri i roto i te vitro, ā, ka aukati i te whakarerekētanga o ngā ara NF-κB me MAPK i puta mai i te UVB. Ko te paninga o te tangohanga kiri pamekaranete ka whakaheke i te COX-2 i roto i te kiri poaka hou i tangohia, ka hua ake he pānga anti-inflammatory nui. Ahakoa e whakaarohia ana ko te waikawa ellegic te wāhanga tino kaha o te tangohanga pamekaranete, i whakaatuhia e te tauira kiore he mahi anti-inflammatory teitei ake me te tangohanga kiri pamekaranete paerewa i whakaritea ki te waikawa ellegic anake. Ko te paninga o te microemulsion o te tangohanga pamekaranete ma te whakamahi i te polysorbate surfactant (Tween 80®) i roto i te whakataurite mata-wehe 12-wiki me te 11 ngā kaupapa, i whakaatu i te hekenga o te melanin (nā te aukati tyrosinase) me te hekenga o te whero i whakaritea ki te mana whakahaere waka.
3.8. Soy
3.8.1. Hītori, Whakamahinga, Kereme
He kai nui te pūmua i roto i ngā pīni soya, ā, he wāhanga koiora hoki e ārai ana i te koroheketanga. Ina koa, he nui ngā isoflavones i roto i ngā pīni soya, ā, he pānga ārai mate pukupuku me ngā pānga rite ki te estrogen nā te hanganga diphenolic. Tērā pea ka ārai ēnei pānga rite ki te estrogen i ētahi o ngā pānga o te menopause ki te koroheketanga o te kiri.
3.8.2. Te Hanganga me te Tikanga Mahi
He nui te pūmua i roto i te soy, mai i te Glycine maxi, ā, kei roto hoki ngā isoflavones, tae atu ki te glycitein, te equol, te daidzein, me te genistein. Tērā pea he pānga estrogenic tō ēnei isoflavones, e kiia ana ko ngā phytoestrogens, ki te tangata.
3.8.3. Ngā Taunakitanga Pūtaiao
He maha ngā isoflavones kei roto i ngā pīni soya, ā, he maha ngā painga ārai-pakeketanga pea. I roto i ētahi atu pānga koiora, e whakaatu ana te glycitein i ngā pānga ārai-pakeke. Ko ngā pūtau kiri i rongoatia ki te glycitein i whakaatu i te pikinga o te tipu me te hekenga o ngā pūtau, te pikinga o te hanganga o te collagen momo I me te III, me te hekenga o te MMP-1. I roto i tētahi rangahau motuhake, i whakakotahihia te tangohanga soya me te tangohanga haematococcus (he nui hoki ngā antioxidants i roto i te rimurimu wai māori), i whakaiti i te whakaaturanga MMP-1 mRNA me te pūmua. Ko Daidzein, he isoflavone soya, kua whakaatu i ngā pānga ārai-wrinkle, whakamārama-kiri, me te whakamakuku kiri. Ka mahi pea a Diadzein mā te whakahohe i te estrogen-receptor-β i roto i te kiri, ka hua ake he whakanui ake i te whakaaturanga o ngā antioxidants taketake me te hekenga o te whakaaturanga o ngā take whakawhiti e arahi ana ki te tipu me te hekenga o ngā keratinocyte. Ko te isoflavonoid equol i ahu mai i te soya i whakanui ake i te collagen me te elastin me te hekenga o ngā MMP i roto i te ahurea pūtau.
E whakaatu ana ētahi atu rangahau kiore in vivo i te hekenga o te mate pūtau i puta mai i te UVB me te hekenga o te matotoru o te kiri i roto i ngā pūtau i muri i te paninga o ngā tangohanga isoflavone. I roto i tētahi rangahau whakamātautau o ngā wāhine 30 kua pāngia e te menopause, ko te whakahaerenga ā-waha o te tangohanga isoflavone mō ngā marama e ono i hua ake ai te matotoru o te kiri me te pikinga o te collagen kiri i inehia e ngā biopsies kiri i ngā wāhi i tiakina e te rā. I roto i tētahi atu rangahau, i aukati ngā isoflavones soy parakore i te mate keratinocyte i puta mai i te UV me te hekenga o te TEWL, te matotoru o te kiri, me te whero i roto i te kiri kiore i pāngia e te UV.
I whakaritea e tētahi RCT matapo-rua matapo o ngā wāhine 30 i waenga i te 45–55 tau te pakeke te paninga o te estrogen me te genistein (soy isoflavone) ki te kiri mō ngā wiki 24. Ahakoa he pai ake ngā hua o te rōpū i pania te estrogen ki te kiri, i whakaatuhia e ngā rōpū e rua he pikinga o te collagen kanohi momo I me te III i runga i ngā koiora kiri o te kiri preauricular. Ka taea e ngā oligopeptides soy te whakaiti i te taupū whero i roto i te kiri (ringaringa) e pāngia ana e te UVB me te whakaiti i ngā pūtau kua wera i te rā me ngā cyclobutene pyrimidine dimers i roto i ngā pūtau kiri matamata kua whakakāhia ki te UVB ex vivo. I whakaatuhia e tētahi whakamātautau haumanu matapo-rua matapo-rua matapo-rua 12-wiki i uru atu ki te 65 ngā kaupapa wāhine me te kino whakaahua kanohi ngawari he whakapainga i te tae kōwhai, te iraira, te mangu, ngā raina angiangi, te kakano kiri, me te tae kiri ina whakaritea ki te rongoā. I te taha o ēnei āhuatanga, ka taea e ēnei āhuatanga te tuku i ngā pānga ārai-pakeketanga pea, engari me nui ake ngā whakamātautau haumanu matapo-rua kaha ake hei whakaatu tika i tōna painga.
4. Kōrero
He pānga ārai-pakeke pea ngā hua tipu, tae atu ki ērā e kōrerohia ana i konei. Ko ngā tikanga o ngā tipu ārai-pakeke ko te kaha ki te tango i ngā rauropi kore utu o ngā antioxidants e pania ana ki te kiri, te whakanui ake i te tiaki i te rā, te whakanui ake i te makuku o te kiri, me ngā pānga maha e arahi ana ki te whakanui ake i te hanganga collagen, te whakaiti rānei i te pakaru o te collagen. He iti noa iho ētahi o ēnei pānga ina whakaritea ki ngā rongoā, engari kāore tēnei e whakaiti i ō rātou painga pea ina whakamahia tahitia me ētahi atu mahi pēnei i te karo i te rā, te whakamahi i ngā parenga-rā, te makuku i ia rā me te maimoatanga tika a te tohunga hauora mō ngā mate kiri o nāianei.
Hei tāpiritanga, ka tukuna e ngā tipu ngā kai matū koiora rerekē mō ngā tūroro e pai ake ana ki te whakamahi i ngā kai "taiao" anake ki ō rātou kiri. Ahakoa kei roto i te taiao ēnei kai, he mea nui kia whakanuia ki ngā tūroro ehara i te mea kāore he pānga kino o ēnei kai, inaa, he maha ngā hua tipu e mōhiotia ana he take pea o te mate pāwera.
I te mea kāore e hiahiatia ana te taumata taunakitanga ōrite mō ngā hua whakapaipai hei whakaatu i te whai huatanga, he uaua ki te whakatau mēnā he pono ngā kereme mō ngā pānga ārai-pakeketanga. Heoi, he maha ngā tipu kua whakarārangihia i konei, he pānga ārai-pakeketanga pea, engari me nui ake ngā whakamātautau haumanu pakari. Ahakoa he uaua ki te matapae me pēhea te whai hua tika o ēnei kaihoko tipu ki ngā tūroro me ngā kaihoko a meake nei, he tino tūponotanga mō te nuinga o ēnei tipu, ka haere tonu te whakauru i ngā whakatakotoranga e whakauru ana i a rātou hei kai hei hua tiaki kiri, ā, ki te mau tonu i te whānuitanga haumaru, te manakohia nuitia e ngā kaihoko, me te utu pai rawa atu, ka noho tonu rātou hei wāhanga o ngā mahi tiaki kiri noa, ka iti noa ngā painga ki te hauora o te kiri. Heoi, mō te iti o ēnei kaihoko tipu, ka nui ake te pānga ki te taupori whānui mā te whakapakari i ngā taunakitanga o tā rātou mahi koiora, mā roto i ngā whakamātautau biomarker paerewa teitei, ā, muri iho ka tukuna ngā whāinga tino whai hua ki te whakamātautau haumanu.
Wā tuku: Mei-11-2023
